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Dying patients to test new drugs



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EXPERIMENTAL drugs are to be given to terminally ill cancer patients in a bid to halve the amount of time it takes to develop new medication.
The Department of Health has given approval for a new unit at St Bartholomew's Hospital, London, where patients who are non-responsive to existing remedies and with no hope of recovery will be given drugs previously untested on humans.

It currentl
y takes an average of ten years to get a new drug approved, but doctors are hoping to halve that length of time for cancer medication.

Professor John Gribben from Barts and The London NHS Trust said: "We're not talking about cutting any corners in terms of patients' safety.

"We would argue that for patients who've got cancer ten years is too long to wait and we've got to try to cut that period down as much as possible."

Blood samples will be analysed within a day and the treatment only continued if it proves effective.

Patients will be given a tiny dose at first to minimise the risk, and only those who have failed to respond to existing medication will take part.

Mr Gribben added: "What we're looking for is drugs that will kill the cancer cells but leave the rest of the patient intact. We're always prepared for very unexpected effects.

"We know for each product that comes along what the potential side-effects might be, and we've got staff who spend a lot of time counselling patients before they sign up to make them aware of the risks and potential lack of benefits."

The unit, which will be officially opened next month, is the first of a network of 19 centres being set up.

The initiative is being funded by the Department of Health and Cancer Research who are providing £400,000 per year.





The full article contains 309 words and appears in The Scotsman newspaper.
Page 1 of 1

  • Last Updated: 21 March 2008 9:49 PM
  • Source: The Scotsman
  • Location: Edinburgh
 
1

Charles Linskaill,

Edinburgh 22/03/2008 01:26:11
Is it on permission of the cancer patient though,?

2

px,

abroad 22/03/2008 08:36:19
Sorry. I don't like this idea. It reminds me of the experiments done n Germany during the second world war by Mengele et. al.
3

Vivas,

Edinburgh 22/03/2008 09:19:51
It will be voluntary and permission based, the ethics of drugs trials demands that.

Imagine any one of ourselves in that situation and what we might do.Some of us will want the peaceful way out, some of us will take it head on and choose last-ditch methods like this. I don't *honestly* know what *I'd* do but I like to *think* I'd take the latter.
4

Robert,

Kirriemuir 22/03/2008 10:15:02
This move is overdue. My late wife was in hospice twice for 2 weeks (on each occasion) and we were both appalled by the absence of experimental therapies. When told by the oncologist (my wife had BC) that further treatment would not be able to help and when left to die she and myself would have welcomed experimental treatment. I took her out of the hospice to spend her remaining days at home, in her own bed, but primarily because we were convinced that the physicians were practicing euthanasia and that was ten years ago. Has anyone ever heard of a hospice not having sufficient bed spaces? Four years later my 45 year old daughter succumbed to BC but she declined to enter the hospice knowing how her mother was treated. (It might be added, as an aside, that physicians should not be in-charge of those units; they do not make good general managers). There are many alternative therapies that could be tested but as they lie outside the specialisation of the medical profession (not being pharmaceutical drugs) their use is avoided. Treatments, such as radio and chemo therapies, simply kill the patient in addition to the cancer while almost all alternative treatments work through boosting the immunity. Let us see how long it takes for those alternative methods to break through the almost resistant conservatism of the medical profession? Incidentally, contrary to many cherished views, cancer is not heredity, the common feature is diet.
5

subrosa,

22/03/2008 12:37:57
# 4

Yes our hospices leave a lot to be desired in the way of alternative treatments. Even the suggestion of trying one of them brings hospice staff to a state of apoplexy. Compared with many European countries we are very introverted regarding holistic medicine. The only way for improvement is for the alternative medicine group to produce evidence for their case and do it forcibly.
6

Eleana,

Bonnyrigg 22/03/2008 23:17:30
I really think this is wrong. Yes - if given a chance of something to help most would agree to try it however one shortcut leads to another, then another and before you know it the ethical arguments are ignored and anything is accepted. Medics have no idea how new drugs will actually react with human beings and I dont think it is morally right to experiment on the dying.
7

Robert,

Kirriemuir 23/03/2008 02:24:37
The dying Eleana, are mostly composmentis and capable of making their own decisions so ethical questions would hardly arise. Although the article relates to pharmaceuticals which few if any physicians would have tested on themselves there are many other benign but beneficial substances such as high doses of unbiquinone which could be administered under the care of a physician so there is no reason whatsoever to hesitate from practicing such experiments. The patient is dying so anything that brings hope and especially if it can subsequently cure well why not test it? The option to participate would hopefully be of the patient's choosing while at this current time it is mainly at the discretion of the physician. I am unable to visualise any problems.

 

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